The plant physiology and molecular biology lab of the Institute of Genetics and Physiology published papers in 2020 on BMC Plant Biology and Journal of Agricultural Biotechnology first reporting the biological characteristics and thermotolerance regulation of wheat heat shock transcription factor TaHsfA2-10 and TaHsfA2-12. These preliminary studies showed the important functions of these 2 genes from the aspects of model plant transformation and phenotype observation. Recently, Wang et. reported on Theoretical and Applied Genetics that 2 transcription factor genes were identified on chromosomes 5A and 5D controlling grain weight and stress tolerance (particularly for thermotolerance) through genome-wide association study (GWAS) for a set of 688 diverse winter wheat accessions. Guo Xiulin et. compared their former results with Wang’s and found out the 2 reported genes are exactly TaHsfA2-10 and TaHsfA2-12. This conclusion further confirmed the important functions of these 2 factors for regulating the thermotolerance of field crop. As global temperature rises, studies for the stress regulations of this gene family and development of molecular markers for drought tolerance and heat tolerance may become a new focus of research on crop thermotolerance.